| 학회 |
한국공업화학회 |
| 학술대회 |
2004년 가을 (10/29 ~ 10/30, 호서대학교(아산캠퍼스)) |
| 권호 |
8권 2호 |
| 발표분야 |
정밀화학 |
| 제목 |
Microwave Assisted Synthesis of 99mTc-2,6-Diisopropylacetanilidoiminodiacetic Acid and Its Analogs: A Hepatobiliary Imaging Agent |
| 초록 |
A rapid procedure for the preparation of 4 discrete compounds around the iminodiacetic acid (IDA) core as well as radiochemical labeling with 99mTc was established. Using a microwave reactor with a rotor carrying a number of reaction vessels, these IDA analogs were prepared conveniently in large scale with an average yield of 33% at a time. 99mTc-2,6-diisopropylacetanilidoiminodiacetic acid (99mTc-DISIDA) and its analogs were synthesized under microwave irradiation in very short reaction times. The microwave irradiation offers a rapid and efficient methodology for the formation of a considerable range of IDA derivatives. The method is expected to be applicable to the preparation of radiopharmaceuticals. |
| 저자 |
박상현, 권희정, 장승호, 신병철, 박경배
|
| 소속 |
한국원자력(연) |
| 키워드 |
microwave irradiation; 99mTc-DISIDA; radiopharmaceuticals
|
| E-Mail |
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