| 학회 | 한국고분자학회 |
| 학술대회 | 2004년 봄 (04/09 ~ 04/10, 고려대학교) |
| 권호 | 29권 1호, p.186 |
| 발표분야 | 의료용 고분자 부문위원회 |
| 제목 | Evaluation of Small Intestinal Submucosa (SIS) Sheet Coated by Alginate and Gelatin for Wound healing |
| 초록 | Dressings have been applied to open wounds for centuries. Traditionally they have been absorbent, permeable materials. With the advent of modern wound care productes many dressings are now capable of absorbing exudate while still continuing to provide a moist wound healing environment. Porcinal small intestinal submucosa (SIS) as a new material mainly composed of collagen, glycosaminoglycan, and various growth factors, has been widely used as organ reconstructions and wound dressing without immuno-rejection responses. In this study, we prepared SIS sheets coated on their surface by alginate and gelatin. As natural polymer, alginate and gelatin were selected to improve wound healing activity. SIS sheets were immersed in 2% alginate solution and 2% gelatin solution for 30 min at room temperature. And we prepared SIS sheets by spreading and freeze-drying. The prepared SIS sheets were evaluated their characteristics such as water uptake ability in various buffers, surface morphology, moisture vapor transmission rate and biocompatibility of NIH/3T3. The biocompatibility of NIH/3T3 was found to be acceptable at cell density of 2×104 cells/cm2. From this study, SIS is regarded as an appropriate biodegradable material able to dress the wound like a burn in substitution of the traditional artificial composite materials the expected to be used as the biological dressings. Key words : small intestinal submucosa, alginate, gelatin Acknowledgement : This work was supported by KMCIE (N11-A08-1402-05-1-3). |
| 저자 | 김선화1, 신혜원1, 장지욱2, 김문석2, 조선행2, 강길선1, 이해방2 |
| 소속 | 1전북대, 2한국화학(연) |
| 키워드 | small intestinal submucosa; alginate; gelatin |
