| 학회 | 한국고분자학회 |
| 학술대회 | 2002년 가을 (10/11 ~ 10/12, 군산대학교) |
| 권호 | 27권 2호, p.190 |
| 발표분야 | 의료용 고분자 부문위원회 |
| 제목 | In vitro Chodrogenic Differentiation of Bone Marrow Derived Mesenchymal Stem Cells in Porous Polymer Scaffolds |
| 초록 | Articular cartilage exhibits little intrinsic repair capacity, and new tissue engineering approaches are being developed to promote cartilage regeneration using cellular therapies. Bone marrow derived mesenchymal stem cells (MSCs) are highly proliferative, and multipotential cells that have been considered as ideal candidate cells for tissue engineering applications. In this study, we have characterized the chondrogenic potential of rabbit MSCs in porous polymer scaffolds (PLGA, PLGA/DBP, and PGA) as three-dimensional constructs to support chondrogenic differentiation following TGF-β1. In vitro, MSCs were seeded in these polymer scaffolds for up to 28 days. The chondrogenesis of MSCs-seeded polymer scaffolds and pellet culture was assessed by histology, immunohistochemistry, and RT-PCR for chondrogenic phenotype. Acknowledgment : This work was supported by MOWH (IMT-2000,01-PJ11-PG9-01NT00-0011). |
| 저자 | 박기숙1, 황혜진2, 장지욱*3, 이상진**, 강길선, 이종문, 이 |
| 소속 | 1전북대, 2*부경대, 3**한국화학(연) |
| 키워드 | |
