| 학회 | 한국고분자학회 |
| 학술대회 | 2003년 봄 (04/11 ~ 04/12, 연세대학교) |
| 권호 | 28권 1호, p.97 |
| 발표분야 | 의료용 고분자 부문위원회 |
| 제목 | In vitro Dissolution Test Evaluation of Simvastatin by Self-microemulsifying |
| 초록 | A self-microemulsifying drug delivery systems (SMEDDS) was developed to improve the oral bioavailability of poorly water soluble drugs because of its ability to improve drug solubilization and potential for enhancing absorption in the gastrointestinal tract, caused by surfactant-induced permeability. Simvastatin, a poorly water soluble drug and widely used for the treatment of hypercholesterolimia, was incorporated into the SMEDDS. Optimized formulations for bioavailability assesment were selected by evaluating the solubility and microemulsion existence range after emulsifying with varying compositions of oil and surfactant-cosurfactant mixtures, and by determination of particle size of the resulting emulsion. The absorption profile from SMEDDS was compared to simvastatin tablet (Zorco® ) by administering as prefilled hard gelatin capsules from the dialysis bag, and the drug content was determined by HPLC. The release pattern of simvastatin was also investigated in gastric and intestinal fluids to evaluate the effect of pH in in vitro dissolution. The SMEDDS formulations of simvastatin showed improvement in absolute oral bioavailability compared with of commercial simvastatin tablet formulation. From this results, it could be possible oral dosage form of simbastatin. Acknowledgement : This work was supported by KMOCIE |
| 저자 | 강복기;서광수;김종민;길희주;정상영;강길선;이해방;조선행 |
| 소속 | 전북대 |
| 키워드 | self-microemulsifying drug delivery systems (SMEDDS); Simvastatin; oral bioavailability |
