| 학회 | 한국고분자학회 |
| 학술대회 | 2005년 가을 (10/13 ~ 10/14, 제주 ICC) |
| 권호 | 30권 2호 |
| 발표분야 | 의료용 고분자 부문위원회 |
| 제목 | Synthesis and characterization of doxorubicin immobilized magnetite and their biomedical application |
| 초록 | Magnetite nanoparticles are suitable for receptor targets because of their colloidal stability, biocompatibility, biodegradability and nontoxicity for the body. Iron oxide nanoparticles are routinely used as a contrast agent for magnetic resonance imaging.1 Polymer coatings enhance their biocompatibility and avoid magnetic aggregation. Surface-modified uptake, ability to target tumor cells and anti-tumor efficacy. Iron oxide nanoparticles were synthesized using dextran by co-precipitation method.2 And dextran coated nanoparticles(DNPs) were reacted with 5wt% 3-(aminopropyl)-trimethoxysilane to produce amino groups on the surface. Finally, the surface of silica-coated DNPs was modified with RGD peptide and doxorubicin(DOX). The surface modification of magnetite nanoparticles internalized into KB cell was visualized using both fluorescence and confocal microscopy. Transmission microscopy(TEM), X-ray diffraction(XRD), Fourier transform spectrometer(FT-IR) and UV-vis Spectrophotometer measurements were employed to examine the surface-modified magnetite nanoparticles. fig1. TEM of DNPs fig2. UV spectra of DNP, DOX and DNP-DOX 1. .Yong Zhang, Nathan Kohler, Miqin Zhang, Biomaterials, 23, 1553-1561 (2002). 2. Chu W.Jung, Magnetic Resonance Imaging, 13, 675-691 (1995) |
| 저자 | 박미진, 강인규 |
| 소속 | 경북대 |
| 키워드 | magnetite; dextran; RGD-peptide; doxorubicin |
