| 초록 |
Biomedical adhesives based on alkyl cyanoacrylates are especially used extensively for joining tissues as hemostatic agents and in healing wounds. Cyanoacrylates are single-part, solvent-free adhesives that form strong bonds on a wide variety of substrates. They harden at room temperature by anionic polymerization initiated either by absorbed moisture or by alkaline sites on the surface. These cyanoacrylate tissue adhesives are expected to be potential for bonding the wounds as compared to the suture. But there is a lack of significant data on the toxicity of cyanoacrylate monomers. So this research was aimed at evaluating in vitro and in vivo biocompatibility of some cyanoacrylates. All the monomers, ethyl cyanoacrylate, octyl cyanoacrylate, ethylhexyl cyanoacrylate and ethyl cyanoacryloyl lactate, were directly prepared by a Knoevenagel reaction. The samples were tested as a polymerized film by using solvent casting method. The weight loss, molecular weights, and molecular weight distribution of the polymerized films were measured under physiological conditions to study in vitro biodegradability of cyanoacrylate polymers which were produced by solution polymerization in methanol. Also amounts of toxic formaldehyde produced by degradation were measured by UV quantitative analysis and fibroblasts were cultured for cytotoxity testing. In addition, the adhesive strength using animal skin were investigated.
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