| 학회 |
한국고분자학회 |
| 학술대회 |
2011년 가을 (10/06 ~ 10/07, 김대중 컨벤션센터) |
| 권호 |
36권 2호 |
| 발표분야 |
기능성고분자－막분리용 고분자 |
| 제목 |
Preparation of iron oxide using PEO -b- PMAHD- DOX for the tumor cell imaging |
| 초록 |
A variety of polymerizations of N-phenylmaleimide(N-PMI) via several mechanisms have been reported by several groups. Especially, anionic polymerization of N-phenylmaleimide(N-PMI) was found to be possible in the mixture of benzene/THF/DMSO at room temperature using polymeric alkoxide as an initiator. In this study the polymeric alkoxide was obtained from n-butyllithium-initiated ring-opening polymerization of ethylene oxide (EO) in the presence of potassium tert-butoxide in the mixture of benzene/DMSO at 35℃, followed by polymerization of N-phenylmaleimide. From the resulting block copolymer, the THF-soluble N-PMI fragment was deimidized in DMSO at 120℃ using hydrazine monohydrate. We can get PEO-b-PMAc and PEO-b-PMAHD depending upon the deimidation condition. PEO-b-PMAHD-DOX could be synthesized by the reaction with doxorubicin in DMSO. The resulting material was used as a polymeric stabilizer for preparation of nano-sized iron oxide particles. |
| 저자 |
조영준, 김유진, 김형철, 최우석, 권난현, 이재혁, 이재열, 강호정, 김정안
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| 소속 |
경희대 |
| 키워드 |
PEO; N-phenylmaleimide; doxorubicine; iron oxide; anti-cancer drug
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| E-Mail |
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