| 학회 |
한국고분자학회 |
| 학술대회 |
2013년 봄 (04/11 ~ 04/12, 대전컨벤션센터) |
| 권호 |
38권 1호 |
| 발표분야 |
고분자합성 |
| 제목 |
Synthesis of DNA-Mimic Polymers based on Polyepichrolohydrin with adenine Moieties and Properties, Structure, Biocompatibility. |
| 초록 |
A series of well-defined brush polymers bearing adenine group were synthesized: poly[oxy(11-(3-(9-adeninyl)propionato)-undecanyl-1-thiomethyl)ethylene] (PECH-AP) and poly[oxy(11-(5-(9-adenylethyloxy)-4-oxopentanoato)undecanyl-1-thiomethyl)-ethylene] (PECH-AS). The adenine-containing polymers were found to form favorably into multi-layer structures, always providing adenine end groups at the film surface. These polymers could be applied easily by conventional coating processes to produce good quality film. Despite the structural similarities, PECH-AS surprisingly exhibited higher hydrophilicity and better water sorption properties than PECH-AP. These differences were attributed to the chemical structures in the bristles of the polymers. The adenine-rich surfaces of the polymer films demonstrated selective protein adsorption, suppressed bacterial adherence, facilitated HEp-2 cell adhesion, and exhibited good biocompatibility in mice. |
| 저자 |
송성진, 김진철, 정정운, 노예철, 김미희, 권원상, 정성민, 권경호, 이진석, Graniel Harne A.Abrenica, 이문호
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| 소속 |
포항공과대 |
| 키워드 |
DNA-mimic; Polymer synthesis; Brush polymer; Multi-bilayer; Biosensor
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| E-Mail |
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