| 학회 |
한국화학공학회 |
| 학술대회 |
2016년 봄 (04/27 ~ 04/29, 부산 BEXCO) |
| 권호 |
22권 1호, p.430 |
| 발표분야 |
생물화공 |
| 제목 |
Hybrid heteronanocrystal for redox-responsive T1/T2 dual-mode magnetic resonance imaging |
| 초록 |
Dual-mode contrast agents (DMCA) for T1- and T2-weighted magnetic resonance (MR) imaging have drawn extensive interest for their ability to improve diagnostic accuracy by providing two complementary and reliable data within single instrument. Herein, we developed an environment-responsive imaging nanosystem based on the hybrid hetenanocrystals functioning magnetic relaxation switch (MRS) for T1/T2 dual-mode MR imaging. The nanoprobes were synthesized by epitaxial growth of redoxable paramagnetic shells on the surface of superparmagnetic cores using thermal decomposition method. Mn3O4 shells were introduced to the nanoplatform to minimize the water proton interaction with the nanoprobe in normal condition before both immediate dissolution generating high-spin Mn2+ ions and MRS activation under intracellular reducing environment. We investigated the OFF/ON operation mechanism of MRS according to glutathione (GSH) levels on in vitro test, and confirmed the feasibility of the nanoprobes for in vivo T1/T2 MR imaging of tumor-bearing mice. |
| 저자 |
김명훈1, 손혜영2, 김가윤1, 허용민2, 함승주1
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| 소속 |
1연세대, 2연세의료원 |
| 키워드 |
기능성바이오/융합소재공학 |
| E-Mail |
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| 원문파일 |
초록 보기 |
