| 학회 |
한국고분자학회 |
| 학술대회 |
2011년 가을 (10/06 ~ 10/07, 김대중 컨벤션센터) |
| 권호 |
36권 2호 |
| 발표분야 |
의료용 고분자 부문위원회 |
| 제목 |
Radiation-crosslinked poly(vinyl alcohol) hydrogel for the transdermal permeation of lidocaine HCl |
| 초록 |
Hydrogels of poly(vinyl alcohol) loaded with lidocaine HCl, an local anesthetic, were prepared by using a γ-irradiation followed by a freeze-thawing. Various formulations were prepared with various amounts of polymer, additives, and initial drug. The dynamic swelling and drug-release behaviors were dependent on the crosslinking density. The release of lidocaine was continued up to 12 h. The hydrogels that were prepared with a higher irradiation released the drug more slowly. The release data were fitted to an empirical equation to estimate the transport parameters, which indicated a non-Fickian trend for drug transport. |
| 저자 |
권희정1, 임윤묵1, 박종석1, 박은지1, 최종배2, 신영민1, 조선영2, 김우진1, 김용수1, 노영창1
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| 소속 |
1한국원자력(연), 2한양대 |
| 키워드 |
Radiation-crosslinking; lidocaine; drug delivery; hydrogels
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| E-Mail |
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