| 초록 |
In this study, we demonstrated the release behavior of amlodipine maleate with the content of mannitol, 2-hydroxy ethyl starch, lactose, microcrystalline cellulose (MCC) and the effect of disintegrating agent and a bonding agent on the release behavior of drug. The release behavior of the tablets was compared with Novalopine® in the simulated gastric fluid (pH 1.2). Differential scanning calorimeter (DSC), X-ray diffraction (XRD), fourier-transform infrared spectroscopy (FT-IR) was measured for the physicochemical characterization of the tablets. In the case of amlodipine maleate blended with mannitol, lactose or MCC, the crystallinity of drug and excipient was disappeared, and the crystallinity of drug was effected by adding PVP. In conclusion the drug release behavior was effected with contents of diluting agent and other excipient. This research was supported by WCU (R31-20029). |
