| 초록 |
The sustained release of bioactive molecules from delivery systems is a common strategy for ensuring their prolonged bioactivity and for minimizing safety issues. However, residual toxic reagents, the use of harsh organic solvents, and complex fabrication procedures in conventional delivery systems are considered enormous impediments towards clinical use. Herein, we describe the porous polycaprolactone (PCL) particles with unique leaf-stacked structures (LSS particles) prepared using clinically feasible materials and procedures. Our findings reveal that LSS particles enable a sustained release of bioactive BMP-2 for sufficient periods, providing an appropriate environment for osteogenic differentiation and new bone formation. Thus, the unique leaf-stacked structures of these LSS particles provide a simple but clinically applicable platform for effectively delivering a variety of bioactive molecules, such as growth factors, cytokines, hormones, peptides, etc. |
