| 학회 |
한국화학공학회 |
| 학술대회 |
2006년 가을 (10/27 ~ 10/28, 고려대학교) |
| 권호 |
12권 2호, p.1367 |
| 발표분야 |
고분자 |
| 제목 |
Antitumor drug of hydrophobically modified glycol chitosan nanoparticles as carrier for camptothecin |
| 초록 |
A water-insoluble antitumor agent, camptothecin (CPT) was successfully incorporated into hydrophobically modified glycol chitosan (HGC) nanoparticles formed by chemically linking 5β-cholanic acid to glycol chitosan chains using 1-ethyl-3-(3-dimethylaminopropyl)-carbodiimide chemistry. CPT-loaded HGC (CPT_HGC) nanoparticles were prepared by a dialysis method. Physicochemical characteristics of CPT-HGC nanoparticles were evaluated by measurement of size, encapsulation efficiency, encapsulation amount and morphology. CPT releases from HGC nanoparticles, in vitro by cellulose membrane dialysis method. And CPT concentrations were determined by HPLC. Cytotoxicity test of CPT-HGC nanoparticles were evaluated in MCF-7 breast cancer cells ,in vitro. In, vivo, the antitumor effects of CPT-HGC nanoparticles was evaluated in tumor-bearing mice by measurement of tumor volume and body weight. In addition, the apoptosis of tumor was conformed by TUNEL assasy. According for the result, CPT-HGC nanoparticles have potential for cancer chemotherapy. |
| 저자 |
민경현1, 김종호2, 김유신3, 박낭운3, 김인산3, 김광명2, 정서영1, 권익찬2
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| 소속 |
1경희대, 2KIST 의과학 연구센터, 3경북대 |
| 키워드 |
camptothecin; hydrophobically modified glycol chitosan; nanoparticle
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| E-Mail |
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| 원문파일 |
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