| 학회 |
한국화학공학회 |
| 학술대회 |
2006년 가을 (10/27 ~ 10/28, 고려대학교) |
| 권호 |
12권 2호, p.1776 |
| 발표분야 |
생물화공 |
| 제목 |
Essential/nonessential amino acid compositions can modulate the proliferation of mesenchymal stem cells |
| 초록 |
Mesenchymal stem cells (MSCs) comprise a rare population of multipotent progenitors capable of supporting hematopoiesis and differentiating into three (osteogenic, adipogenic, and chondrogenic) or more (myogenic, cardiomyogenic, etc.) lineages. Due to this ability, MSCs appear to be an attractive tool in the context of tissue engineering and cell-based therapy. Bone marrow and umbilical cord represents the main source of MSCs for both experimental and clinical studies. Currently, the stimulatory effects of various nutrients upon the growth rate of cells in vitro have been investigated extensively. In this study, we evaluated the effects of essential/nonessential amino acid on the proliferation of MSCs originated from bone marrow and umbilical cord. Both MSCs were seeded at a density of 2.5 X 103 cells/cm2 and cultured in various amino acid compositions for eight days. And MTT, LDH, FACS, morphology analyses were performed. As a result, amino acid composition could modulate the proliferation of MSCs but the degree of effect was dependent on the cell sources. |
| 저자 |
최경민1, 윤희훈1, 서영권1, 한미정1, 권순용2, 이화성2, 송계용3, 김영진4, 박정극1
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| 소속 |
1동국대, 2카톨릭대, 3중앙대, 4라이프코드 |
| 키워드 |
Essential/nonessential amino acid; mesenchymal stem cell; proliferation
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| E-Mail |
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| 원문파일 |
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