| 학회 |
한국고분자학회 |
| 학술대회 |
2011년 봄 (04/07 ~ 04/08, 대전컨벤션센터) |
| 권호 |
36권 1호 |
| 발표분야 |
의료용 고분자 |
| 제목 |
Preparation and Characterizationof Valsartan Loaded Polyoxalate Microspheres |
| 초록 |
One of major challenges in the drug delivery lies in the development of microspheres that are effectively delivered to release their payload over an extended period to achieve a clinical response. We prepared valsartan loaded polyoxalate that reported as a new family of biocompatible and biodegradable polymer. Microspheres were prepared using a simple method based on an emulsion-solvent evaporation method with various conditions. The polyoxalate molecular weight and concentration of cosurfactant dominated the structure of polyoxalate microsphere, in vitro degradation and drug release profiles of microspheres. Valsartan loaded polyoxalate microspheres had a diameter from 200 nm to 80 m. Drug release profiles from valsartan loaded polyoxalate microspheres can be controlled. We anticipate great potential of valsartan loaded polyoxalate microspheres for controlled and sustained drug delivery. This research was supported by WCU (R31-20029). |
| 저자 |
유석철, 홍동현, 송병주, 조원형, 송이슬, 이동원, 강길선
|
| 소속 |
전북대 |
| 키워드 |
Valsartan; Polyoxalate; Microspheres
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| E-Mail |
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