| 학회 |
한국고분자학회 |
| 학술대회 |
2006년 봄 (04/06 ~ 04/07, 일산킨텍스) |
| 권호 |
31권 1호 |
| 발표분야 |
의료용 고분자 부문위원회 |
| 제목 |
Thermosensitive poly(organophosphazene) hydrogel for injectable tissue engineering applications |
| 초록 |
The poly(organophosphazene) hydrogel which exhibited the thermoreversible sol-gel transition behavior against the temperature was synthesized. A viscometric measurement indicated that the thermosensitive hydrogel could be formed at body temperature from the polymer solutions in concentrations of 10 wt%. In this work, the poly(organophosphazene) hydrogel was evaluated as an injectable tissue engineering matrix in vivo system. 10 wt% solution of poly(organophosphazene) containing MC3T3-E1 mouse preosteoblast and collagen was subcutaneously injected into the nude mice. Cellular proliferation gradually increased during the injection period given in the concentration of collagen (0.01 wt%). Proliferation of MC3T3-E1 cells is dramatically enhanced in the poly(organophosphazene) hydrogel containing collagen in a nude mouse model. These results suggest that poly(organophosphazene) hydrogel containing collagen is utilized as injectable cell carrier for tissue engineering applications. |
| 저자 |
윤지연, 송수창
|
| 소속 |
한국과학기술(연) |
| 키워드 |
poly(organophosphazene); hydrogel; thermosensitive; injectable tissue engineering
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| E-Mail |
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