| 학회 |
한국화학공학회 |
| 학술대회 |
2003년 봄 (04/25 ~ 04/26, 순천대학교) |
| 권호 |
9권 1호, p.388 |
| 발표분야 |
분리기술 |
| 제목 |
SMB Chromatography를 이용한 광학이성질체 분리 |
| 초록 |
Simulated moving bed(SMB) chromatography has been recognized an essential tool for the optical separation of chiral drug racemates. Racemates-Bupivacaine with chiral characteristics has been used for a local anaesthetic. R-(+)-Bupivacaine is more toxic to the central nervous and the cardiovascular systems. In this work, lab-scale SMB consists of 8 columns of 10mm I.D.×100mm Length was employed for the separation of the chiral drug . Used Chiral Stationary Phase was Kromasil CHI-TBB with a particle size of 5㎛ . In order to optimize the SMB Chromatography parameters, the simulation was carried out by using "Aspen chromatography" software of "Aspen tech." and compared its results with that of experimental work.
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| 저자 |
윤지연1, 김소영1, 이중기2, 박태진2, 서성섭1
|
| 소속 |
1홍익대, 2한국과학기술(연) |
| 키워드 |
bupivacaine; smb; separation
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| E-Mail |
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