| 학회 | 한국고분자학회 |
| 학술대회 | 2002년 가을 (10/11 ~ 10/12, 군산대학교) |
| 권호 | 27권 2호, p.188 |
| 발표분야 | 의료용 고분자 부문위원회 |
| 제목 | Anti-bone Resorption of Pamidronate-loaded PLGA Wafer in Experimental Aural Cholesteatoma |
| 초록 | Pamidronate disodium (PD) is an important representative of the bisphosphonates, potently inhibit bone resortion and is used for the treatment of bone disease such as osteoporosis, hypercalcemia of malignancy and Paget's disease. In this study, PD is chosen as a model drug due to its lower autotoxicity than other bisphosphonates. PD was incorporated into poly(L-lactide-co -glycolide) (PLGA), drug carrier, for homogeneous mixing and fabricated into the wafer. We investigated the release pattern of PD from PD/PLGA wafers and utilized these wafers in experimental aural cholesteatoma which was induced by ear canal ligation (ECL) method. We measured the number and the surface of osteoclast from the capitatum of mongolian gerbil in which PD/PLGA wafers were implanted to evaluate effect of PD. The osteoclast cell number and surface decreased in PD/PLGA treated group indicating that the sustained release of PD could suppress the osteoclstic bone resorption at the area adjacent to the experimental cholesteatoma. Acknowledgment : This work was supported by KMOCIE (B49-990-5411-05-1-3). |
| 저자 | 유제영1, 김범중*2, 강길선3, 성하수**4, 김형종***5, 정제교****, 이정식****, 이해방** |
| 소속 | 1전북대, 2*전북대, 3**한국화학(연), 4***한림의대 이비인후과, 5****삼천당제약 중앙(연) |
| 키워드 | Pamidronate disodium; Cholesteatoma; Bone Resorption; |
