| 학회 |
한국고분자학회 |
| 학술대회 |
2009년 가을 (10/08 ~ 10/09, 광주과학기술원 오룡관) |
| 권호 |
34권 2호 |
| 발표분야 |
의료용 고분자 부문위원회 |
| 제목 |
Improvement of Pranlukast Dissolution by eudragit L100 |
| 초록 |
Abstract: The aim of this study is to overcome solubility of poorly water soluble drugs. We prepared solid dispersion containing nanoparticle of improvement of dissolution property pranlukast by using spray dryer. This solid dispersions formulated to improvement of dissolution using eudragit L100 as a water soluble for the solid dispersion using poloxamer as a surfactant. Characterization of pranlukast solid dispersion analyzed by particle size analyzer, DSC, XRD, TGA and FT-IR. The in vitro test was carried out to find about improvement of dissolution rate of pranlukast solid dispersion in intestinal juice(pH 6.8), controlled experiment compared pranlukast solid disperion with conventional drugs(Onon). This studies displayed improvement of dissolution of prepared solid dispersion by using spray drying, poorly water soluble of pranlukast as orally pharmaceutical formulation. This research was supported by WCU(R31-20029). |
| 저자 |
이영현, 김윤태, 김대성, 김원, 송이슬, 이종문, 이동원, 강길선
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| 소속 |
전북대 |
| 키워드 |
pranlukast; solid dispersion; eudragit L100; spray-drying
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| E-Mail |
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