| 초록 |
Self-assembled nanoparticles, composed of amphiphilic HA derivatives, have emerged as promising anticancer drug carrier because they can specifically binds to HA receptor (CD44) over-expressed on cancer cells. Despite their tumor-targetability, stability of the nanoparticles in the blood stream still remains a major challenging issue for their in vivo applications. In this study, to improve the stability of nanoparticles we have prepared disulfide crosslinked HA-nanoparticles (CL-HANPs) from pyridyldisulfide bearing HA-b-poly(caprolactone) (HA(PDA)-b-PCL) copolymers via a facile crosslinking method. From the in vitro characterization and in vivo biodistribution, we demonstrated the enhanced structural stability and robust release of drugs. Overall, these results suggest that CL-HANPs might be a promising carrier for intracellular delivery of hydrophobic anticancer drugs with minimum side effects. |
