| 초록 |
Self-assembled hyaluronic acid nanoparticles (HANPs) have potential as drug carriers for rheumatoid arthritis (RA) since HA specifically binds to the receptor (CD44) which is over-expressed in the inflammatory site by RA. In this research, we prepared the HA derivative with the linkage that is degradable in the acidic condition such as the inflamed joint of RA. The hydrophobic drug, methotrexate (MTX), was efficiently encapsulated into HANPs. The results show that MTX is rapidly released under the acidic condition after HANPs reach the inflammatory site. The characteristics of pH-responsive HANPs were confirmed using 1H-NMR and DLS. In vitro study indicated that pH-responsive HANPs were efficiently taken up by RAW 264.7 cells. From in vivo experiment, it was confirmed which pH-responsive HANPs were selectively accumulated at the inflammatory joint of collagen-induced arthritis mice model. These results imply that pH-responsive HANPs have potential as drug carrier for treatment of RA |
