| 학회 |
한국고분자학회 |
| 학술대회 |
2012년 봄 (04/12 ~ 04/13, 대전컨벤션센터) |
| 권호 |
37권 1호 |
| 발표분야 |
Biopolymer-Based Hybrid Materials for Sensing and Delivery |
| 제목 |
Benzoboroxole-containing polymers for glucose sensing and insulin delivery |
| 초록 |
Reversible covalent bond formation between organoboronic acids and biological diols has been used as a chemical way of detecting glucose in the medium. Boronate-diol ester can only be stabilized in relatively high pH conditions, which makes the use of boronic acid-containing polymers difficult to find in vivo applications such as insulin delivery and non-invasive glucose sensors. We synthesized new types of boronic acid-containing polymers and block copolymers based on benzoboroxole. The resulting polymers and block copolymers showed a good affinity toward monosaccharides such as glucose and fructose. In particular, block copolymers containing a polyboroxole block exhibited sugar-responsive behaviors in the presence of glucose at neutral pH, which can be used for building self-regulating insulin delivery systems and sensors. |
| 저자 |
김현규, 정은선, 김경택
|
| 소속 |
UNIST |
| 키워드 |
benzoboroxole; insulin; glucose
|
| E-Mail |
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