| 학회 |
한국고분자학회 |
| 학술대회 |
2012년 가을 (10/11 ~ 10/12, 창원컨벤션센터) |
| 권호 |
37권 2호 |
| 발표분야 |
의료용 고분자 부문위원회 |
| 제목 |
Effect of PLGA/Silk Fibroin Hybrid Film and Scaffold on Proliferation and Attachment of Olfactory Ensheathing Cells |
| 초록 |
Poly(lactic-co-glycolic acid) (PLGA) has been widely applied to tissue engineering as a good biocompatible material and biodegradable synthetic polymer with acceptable mechanical strength. Silk fibroin contains powerful bioactive molecules and useful biomaterials in a range of applications. We fabricated PLGA/Silk fibroin hybrid film and scaffold using 0, 10, 20, 40 and 80 wt% of silk fibroin. Olfactory ensheathing cells (OECs) were seeded on PLGA/Silk fibroin hybrid film, scaffold and confirmed the influence of adhesion and proliferation according to content of silk fibroin. Cell proliferation and viability were measured via MTT assay. In addition, morphology of cellular was adhesion by scanning electron microscope (SEM). In this study, we confirmed PLGA/Silk fibroin hybrid film and scaffold including 40 and 80 wt% of silk provide suitable environment for growth and proliferation of OECs. This research was supported by WCU (R31-20029) and SCRC (SC4110). |
| 저자 |
이정환, 조선아, 이윤미, 배정우, 이동원, 강길선
|
| 소속 |
전북대 |
| 키워드 |
Silk fibroin; Poly (lactic-co-glycolic acid) (PLGA); Olfactory ensheathing cells
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| E-Mail |
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