| 학회 |
한국고분자학회 |
| 학술대회 |
2010년 봄 (04/08 ~ 04/09, 대전컨벤션센터) |
| 권호 |
35권 1호 |
| 발표분야 |
의료용 고분자 부문위원회 |
| 제목 |
Chitosan Nanoparticles Functionalized by the M Cell-Homing Peptide for Oral Vaccine Delivery |
| 초록 |
M cells are located in the follicle associated epithelium in the Peyer`s patch (PP) region. Identification of the markers recognized by M cells is vital not only to study the action mechanism of M cells but also to produce highly effective oral vaccines targeting to M cell. By utilizing M13 phage library together with an in vitro M cell model, we isolated a specific M cell-targeting phage clone, encoding CKSTHPLSC (CKS9) and validated the specificity of this peptide to the PP in ex-vivo. In vitro and in vivo experimental indicated that the CKS9-CNs possess the more specific accumulation property into M cells in the Peyer`s patch region in comparison with control. Therefore, it can be expected that the homing peptide-immobilized chitosan nanoparticles will be a promising carriers for intestinal mucosal vaccination due to the strong binding character of the nanoparticles to the M cells. |
| 저자 |
이상준1, Hieu Quang Vu1, 차혜련2, 이화정3, 유미경4, 나희삼5, 이현철5, 조종수4, 박인규6
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| 소속 |
1전남의대 의생명과학과 / 전남의대 임상백신연구사업단, 2전남의대 의생명과학과, 3전남의대 의생명과학과 / 전남대병원 심장질환 특성화센터, 4서울대 농생명공학부, 5전남의대 미생물학과, 6전남의대 의생명과학과 / GIST 바이오광학영상센터 |
| 키워드 |
oral vaccine; M cell; chitosan nanoparticle
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| E-Mail |
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