| 학회 |
한국고분자학회 |
| 학술대회 |
2014년 봄 (04/10 ~ 04/11, 대전 컨벤션센터) |
| 권호 |
39권 1호 |
| 발표분야 |
휴먼인터페이스 의료용 고분자재료 (의료용 고분자 부문위원회) |
| 제목 |
Nanostructured Mucoadhesive Microparticles for Enhanced Bioavailability of Brimonidine |
| 초록 |
Topical drug administration is used to treat eye diseases due to ease of administration, which, however, is limited in short residence time and low bioavailability of drug. To resolve this, we developed nanostructured microparticles (NMs) of poly (lactic-co-glycolic acid) containing a mucoadhesive polymer (polyethylene glycol) to synergistically enhance ocular retention and thus to obtain higher bioavailability of drug. NMs were prepared by freeze-milling the eletrospun nanofibers to maintain the nanostructure, providing microparticles with a 10-fold increase in specific surface area, as compared with spherical microparticles. NMs contained Brimonidine as a model drug, and were formulated in a dry dosage form for administration. In vivo animal study revealed mucoadhesive NMs show the best results of 13 h in lowering intraocular pressure (IOP), while the periods of lowered IOP were 9-10 and 6 h for other types of microparticles and Alphagan P (marketed product of BRT), respectively. |
| 저자 |
박천권, 박민, 이승호, 최성윤, 이원석, 최영빈
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| 소속 |
서울대 |
| 키워드 |
brimonidine; intraocular pressure; mucoadhesion; nanostructured microparticle; specific surface area
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| E-Mail |
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