| 초록 |
Topical drug administration is widely used to treat various eye diseases due to ease of administration, which, however, is still limited in short residence time and low bioavailability of drug. To resolve this, we fabricated mucoadhesive nano-structured microparticles of large surface area in a dry table to increase the retention time of microparticles as a potential drug carrier on the eye surface in this study. In vivo animal study revealed that a comparable amount of NM with PEG in a tablet form resided on the preocular surface for up to 90 min while other types of micropaticles were cleared away. |
