| 학회 |
한국공업화학회 |
| 학술대회 |
2021년 봄 (05/12 ~ 05/14, 부산 벡스코(BEXCO)) |
| 권호 |
25권 1호 |
| 발표분야 |
포스터-생체재료 |
| 제목 |
Injectable Hyaluronic Acid-based Hydrogel Combined with Vitamin D to Treat Tendinopathy |
| 초록 |
Tendinopathy, also called tendonitis, is one of the most common overuse injuries that includes pain, swelling, and impaired function. Most treatments of tendinopathy provide only symptomatic relief such as rest and steroid injection. Herein, we suggest the efficient of vitamin D (Vit D) delivery system with hyaluronic acid (HA) which is one of the chief components of the extracellular matrix and has a capability of the inflammatory response and wound healing. It is demonstrated that injectable HA hydrogel incorporated with Vit D has an outstanding efficiency for damaged tenocyte proliferation with TNF-α in vitro. Moreover, it showed histological restoration to damaged achilles tendon by collagenase injury rat model. Accordingly, this Vit D delivery system would be a great promising treatment for tendinopathy on intramuscular injection. |
| 저자 |
김준혁1, 김다슬1, 김태형2, 민경훈1, 한동근1
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| 소속 |
1차의과학대, 2중앙대 |
| 키워드 |
Tendinopathy; Vitamin D; Hydrogel
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| E-Mail |
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