| 학회 |
한국공업화학회 |
| 학술대회 |
2021년 가을 (11/03 ~ 11/05, 대구 엑스코(EXCO)) |
| 권호 |
25권 2호 |
| 발표분야 |
포스터-생체재료 |
| 제목 |
An injectable advanced hydrogel with brain-decellularized ECM, PDRN, and TIEVs for spinal cord regeneration |
| 초록 |
A spinal cord injury (SCI) is serious damage to the spinal cord including neurons that causes temporary or permanent changes in its function. In this study, we designed a hyaluronic acid (HA)-based hydrogel combined with decellularized brain matrix (DBM), polydeoxyribonucleotide (PDRN), TNF-α/IFN-γ primed mesenchymal stem cell-derived extracellular vesicles (TIEVs), and neural progenitor cells (NPCs). The advanced hydrogel could promote the proliferation and differentiation of NPCs in vitro. This system can replace injured nerve cells and assist regeneration of spinal cord tissue in a non-invasive way. Thus, the advanced hydrogel with NPCs would be an effective candidate for SCI regeneration. |
| 저자 |
박소연1, 김다슬1, 김준혁1, 노은지2, 한인보2, 유승권3, 한동근1
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| 소속 |
1차의과학대, 2분당차병원, 3고려대 |
| 키워드 |
Spinal cord injury; Hydrogel; DBM; Neural progenitor cell
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| E-Mail |
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