| 초록 |
Recent advances in synthetic polymer chemistry have allowed the generation of simple, protein-like structures with biological activity from synthetic designer polymers. To mimic the biological functions of the natural proteins, many synthetic approaches have incorporated vinyl monomers bearing the constitutional amino acid residues found in nature. Unlike many other existing approaches in the literatures, we present to employ functional polyethers bearing amino acid side chains. Toward this end, we develop a library of a novel class of well-defined, functional epoxide monomers, which are polymerized into functional peptidomimetic polyethers via anionic ring-opening polymerization. Two specific examples toward mimicking the marine mussel foot proteins and the antimicrobial peptides secreted from frog will be presented with their future biomedical applications. |
