| 초록 |
Recently, various types of plant-derived lectins have been utilized for therapeutic cancer treatment. Among them, alueria aurentia lectin (AAL) has a specific binding affinity towards pancreatic cancer cells and induces apoptosis of cancer cells. Hence, we hypothesized that AAL would be available as new pancreatic cancer therapeutics. Herein, coacervate (Coa), a complex of mPEGylated poly(ethylene arginylaspartate diglyceride), heparin, and AAL, has been developed as AAL delivery system for cancer microenvironment. This Coa exhibits a burst AAL release profile at pH 6.5 compared with pH 7.4. In addition, AAL exhibited PANC-1 specific apoptotic activity without any affect to normal cells. Moreover, Coa-mediated AAL delivery system induced target cancer cell death than bolus AAL by maintaining bioactivity, bioavailability, and therapeutic dose of AAL. Therefore, AAL could be used as a novel pancreatic cancer specific therapeutics and Coa could be used as an AAL delivery system. |
