| 초록 |
Living cells are exposed to complex and functional microenvironment including soluble macromolecules, biophysical cues, and interactions between cell-cell and cell-extracellular matrix (ECM). This suggests that the design and manipulation of engineered cellular microenvironments is great important in a wide variety of biological applications such as medicine, and developing in vitro disease models. Compared with the effects of soluble macromolecules and biophysical cues, the extent and importance of architecture of ECMs or tissue in defining cellular function are currently poorly understood. Namely, the architecture effects of ECMs or specific tissues are mainly neglected or minimized as a considering factor for most in vitro and in vivo experimentaton. In this talk, I will present multidisciplinary efforts directed towards the development of multiscale engineerd biomimetic systems for biomedical applications. |
