| 학회 |
한국공업화학회 |
| 학술대회 |
2020년 가을 (10/28 ~ 10/30, 광주 김대중컨벤션센터(Kimdaejung Convention Center)) |
| 권호 |
24권 1호 |
| 발표분야 |
[국제협력] Korea-Vietnam Recent Research Trend in Green & Biological Materials |
| 제목 |
Self-Luminescent Photodynamic Therapy with Biomaterials |
| 초록 |
Despite the potential of photodynamic therapy (PDT), its comprehensive use in cancer treatment is often limited because of the non-degradable risks of photosensitizing drugs and inefficient light penetration and instrumentation. Here we present bioluminescence (BL)-induced proteinous PDT (BLiP-PDT), through the combination of luciferase and an ROS-generating protein (Luc-RGP), which is self-luminescent and degradable as a biomateral. After exposure to naturally occurring substrates without external light irradiation, Luc-RGP fused with a small lead peptide induced breast cancer cell death through the generation of BL-sensitive ROS in the plasma membrane. Even with extremely low light energy, BLiP-PDT exhibited remarkable targeted effects in primary breast cancer cells from patients and in in vivo tumor xenograft mouse models. These findings suggest that BLiP-PDT is immediately useful as a new theranostic approach against various cancers. |
| 저자 |
김영필 |
| 소속 |
한양대 |
| 키워드 |
PDT; bioluminescence; luciferase; ROS; photosensitizer; cancer therapy
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| E-Mail |
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