| 초록 |
Poly(vinyl alcohol) (PVA) hydrogels have been widely utilized for wound dressing, drug carrier and bulking agent (or filler), owing to their good biocompatibility, mechanical properties and high water content. PVA hydrogels have usually produced by chemical (using crosslinkers) or physical (using freeze-thaw technique) crosslinking of PVA chains. However, the residual toxic crosslinking agents in the hydrogel or long processing time are considered as practical limitations. In this study, the PVA hydrogel patches were fabricated by a simple quenching method developed by our laboratory. This method does not need any toxic crosslinking agents nor include time-consuming steps for hydrogel formation. To enhance the physical and wound healing properties of the PVA hydrogel patch, some additives including alginate and aloe vera were introduced into the patch. Their wound healing behaviors were investigated by animal study using a SD rat wound model. |
