| 초록 |
Relatively low pH was found in tumor tissue, and this is widely used for controlled drug delivery. Herein, we fabricated multifunctional optical probes composed of polyaniline (PAni) and pyrene butyric acid (Pyba). In this confined nanostructure, Pyba was used as stabilizer and as localized dopant for the nanocomposite. The nanocomposite was fabricated with various ratios between PAni and Pyba because of searching for an identical ratio for expressing the proper absorbance and fluorescent properties to detect surrounding pH value. We confirmed successful fabrication of PAni nanocomposite and exhibition of different optical characteristics according to pH. We have successfully fabricated nanocomposite, which is composed of polyaniline (PAni) and pyrene butyric acid (Pyba) via solvent shift method, and the outer layer was enclosed by Tween 80 as a surfactant. First of all, the various ratios between PAni and Pyba were applied for synthesis of polyaniline nanocomposite, and an identical condition for exhibition of proper absorbance and fluorescence properties was found out. The morphology of polyaniline nanocomposite was confirmed via scanning electron microscopic imaging and hydrodynamic size was also confirmed by dynamic light scattering method. We demonstrated that confined self-doped polyaniline nanocomposite as a pH sensing agent are preserved in the doped state even at a neutral pH value. Especially, PAni exhibited strong convertible property at absorbance spectra, on the other hand, Pyba showed changing property at fluorescence spectra at various pH values. |
