| 학회 |
한국공업화학회 |
| 학술대회 |
2008년 봄 (05/09 ~ 05/10, 한양대학교(안산)) |
| 권호 |
12권 1호 |
| 발표분야 |
고분자 |
| 제목 |
Cisplatin-Loaded Carboxymethyl Chitosan Nanoparticles formed by ion complex formation |
| 초록 |
Carboxymethyl chitosan(CMCh) was prepared by chemical reaction with mono-chloroacetic acid and glyoxylic acid to low molecular weight water soluble chitosan(LMWSC) of C6-OH (O-Carboxymethyl chitosan) and C2-NH2 (N-Carboxymethylc chitosan) group to apply as gene and drug carrier. Cisplatin is one of the most widely used antitumor drugs in the treatment of a variety of solid tumors. CDDP loaded CMCh(Cis-CMCh) nanoparticles were prepared by ion-complex and investigated by TEM , DLS measurement. The average diameter, drug content, and drug loading efficiency of Cis-CMCs-NP were 300.5nm, 7.1% (w/w), and 76.0%, respectively. |
| 저자 |
남정표, 허선행, 정현, 김동곤, 정영일, 장미경, 나재운
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| 소속 |
순천대 |
| 키워드 |
carboxymethyl chitosan; LMWSC; Cis-CMCh; cisplatin.
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| E-Mail |
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