| 초록 |
Molecular imprinting can easily create recognition sites in polymer matrices. Molecularly imprinted polymers (MIPs) can be prepared by various polymerization methods in the presence of template molecules. MIPs can selectively bind the imprinted enantiomer from a racemate solution and can able to separate target molecules from substrates of a similar structure. MIPs have been widely used as solid separation media, in liquid chromatographies, affinity based solid-phase extraction for separations of chiral compounds and amino acid derivatives. Spherical polymer beads can be prepared by various polymerization methods. Suspension polymerisation is one of the most well suited methods to obtain MIP microspheres. In a continuation to our previous research on the development of MIPs and their applications, the present work focuses on the characterizations of D-Phe imprinted microsphere polymeric beads prepared by modified suspension polymerization. Prepared D-Phe imprinted MIPMs were evaluated as HPLC stationary phase for the chiral separation of Phe enantiomers. |
