| 학회 | 한국화학공학회 |
| 학술대회 | 2013년 봄 (04/24 ~ 04/26, 광주 김대중컨벤션센터) |
| 권호 | 19권 1호, p.338 |
| 발표분야 | 분리기술 |
| 제목 | Preparation of Carbamazepine-Sacchrin Co-crystal via Anti-solvent crystallization and process monitoring via ATR FT-IR |
| 초록 | The co-crystal approach has been investigated extensively over the last decade as one of the most promising methods to enhance the dissolution properties of insoluble drug substances. In this study, high-purity carbamazepine saccharin (CBZ SAC) co-crystals were manufactured by a novel method, anti-solvent addition. When water was added to the methanol solution of CBZ and SAC at room temperature under agitation, nucleation of CBZ SAC co crystals occurred within 2–3 min. Co-crystallization was complete after 30 min, giving a solid yield as high as 84.5% on a CBZ basis. The effects of initial concentrations, focusing on the SAC/CBZ ratio, were examined to establish optimal conditions. The whole anti-solvent co-crystallization process was monitored online via ATR-FTIR analysis of regularly sampled solutions. In conclusion, an anti-solvent approach can be used to produce highly pure CBZ-SAC co crystal powders with a high solid yield. |
| 저자 | 왕인천1, 최광진2, 이민정1, 천난희2 |
| 소속 | 1인제대, 2순천향대 |
| 키워드 | Carbamazepine; Co-crystal; Anti-solvent; Saccharin; ATR-FRIR |
| 원문파일 | 초록 보기 |
