| 초록 |
Significant progress in developing cell-based biohybrid actuators has increasingly been studied. For example, contractile stresses and forces of single cells and cell sheets of cardiomyocytes and skeletal myotubes cultured on micro-cantilevers have been measured. In this study, the integrated cell-based bio-actuator was fabricated by DLP 3D printer and subsequently filling the cell-matrix composed of collagen, Matrigel and Myoblasts. In parallel, we prepared a hydrogel actuator consisting of two different layers with significantly different stiffness and capacities to uptake water in response of the environments. Next, electrical stimulation triggered contraction of cells in the muscle band and movement of the integrated cell-based actuator. This cell-based bioactuator system could be further developed as a integrated cellular machines and systems to provide drug screening, programmable tissue engineering, and biomimetic machine design. |
