| 학회 |
한국고분자학회 |
| 학술대회 |
2010년 봄 (04/08 ~ 04/09, 대전컨벤션센터) |
| 권호 |
35권 1호 |
| 발표분야 |
의료용 고분자 부문위원회 |
| 제목 |
Self-emulsifying Drug Delivery System for Improvement Stability of Docetaxel |
| 초록 |
The poor water-solubility of Docetaxel (Dtx) can be improved by the self-microemulsifying system (SMES). SMES may be a promising way to load hydrophobic Dtx in delivery system. We report on the preparation of Dtx-loaded SMES using PLGA, Tetraglycol, Labrasol, and Cremophor ELP. The average size of the Dtx-loaded SMES determined from the DLS was in the range of 8090 nm. The zeta-potential of the Dtx-loaded SMES indicates the negative surface charges. The changes of PLGA molecular weight did not significantly affect the size of the resultant Dtx-loaded SMES. Dtx-loaded SMES showed good stability in DW and BSA condition at 37oC for 7days. Dtx-loaded SMES showed an inhibitory effect on B16F10 melanoma proliferation. Thus, it appeared that the slightly improved inhibition of B16F10 cell may be due to the Dtx-loaded SMES’s stability. In conclusion, we confirmed that Dtx-loaded SMES showed an inhibitory effect for proliferation of B16F10 melanoma cells. |
| 저자 |
김경해, 강윤미, 김이슬, 강꽃님, 이빛나, 민병헌, 김재호, 김문석
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| 소속 |
아주대 |
| 키워드 |
docetaxel; self-emulsifing drug delivery system
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| E-Mail |
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