| 학회 |
한국고분자학회 |
| 학술대회 |
2008년 봄 (04/10 ~ 04/11, 컨벤션 뷰로(대전)) |
| 권호 |
33권 1호 |
| 발표분야 |
줄기세포 제어 고분자 |
| 제목 |
Targeted Delivery of Endothelial Progenitor Cells using Biodegradable Scaffold enhances the neovascularization in skin |
| 초록 |
Endothelial progenitor cells (EPCs) act as endothelial precursors that promote new blood vessel formation, and increase angiogenesis by secreting growth factors and cytokines in ischemic tissues. However, their engraftment into host vasculature has been estimated to be rare due to the lack of efficient cell delivery system. These facts prompt the hypothesis that targeted delivery of EPC using biodegradable scaffold might improve the vascular engraftment of EPC and subsequently enhance the neovasculariation. When EPC-preseeded biodegradable scaffolds were implanted into the cutaneous wound site, they significantly enhanced the vascular engraftment of EPC and improved the dermal neovascularization as compared with intradermal injection of EPC around wound sites. This work was supported by the Korean Research Foundation Grant funded by the Korean Government (KRF-2006-311-E00293) and Basic Research Program of the Korea Science and Engineering Foundation (R01-2007-000-11246-0). |
| 저자 |
서원희1, 김경리2, 한동근3, 송선화4, 김지연1
|
| 소속 |
1포천중문의과대, 2성균관대, 3한국과학기술(연), 4바이오소재연구센터 |
| 키워드 |
neovascularization; endothelial progenitor cell
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| E-Mail |
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