| 초록 |
The damage of endothelial layer for stent implantation is a critical factor for restenosis and thrombosis. Restoration of damaged endothelium might be well-built way to reduce late stent thrombosis and restenosis. Some reports demonstrated that endothelial progenitor cell (EPC) can differentiate to endothelial cell and thereby accelerate endothelialization. Some chemokines such as stromal cell derived factor-1α (SDF-1α) and granulocyte colony-stimulating factor (G-CSF) are known to involve in the mobilization and homing of EPC. We hypothesized that chemokine-coated stents may mobilize EPC from bone marrow and home EPC to the injured site due to stenting. In this study, chemokine-coated stents were prepared by our methods and characterized in aspect of chemokine release rate, chemotaxis, and the adhesion and migration of EPC. Consequently, Chemokine-coated stents may be a break-through for solving problems of the existing drug-eluting stents. |
