| 학회 |
한국공업화학회 |
| 학술대회 |
2017년 봄 (05/10 ~ 05/12, 광주 김대중컨벤센센터(Kimdaejung Convention Center)) |
| 권호 |
21권 1호 |
| 발표분야 |
(생물공학) 4차 산업혁명을 선도하는 생물공학 신기술 |
| 제목 |
For Prolonged Life Span of Therapeutic Antibodies and Human |
| 초록 |
Human serum IgG shows long circulating half-life (~ 3 weeks) in sharp contrast to other protein therapeutics and its lifespan is highly variable depending on the interaction of Fc domain and FcRn. Association of IgG Fc domain into FcRn at slight acidic endosome and dissociation of the Fc-FcRn complex in serum allow intracellular trafficking of IgG antibodies and recycling, which in turn leads to prolonged serum half-life of IgG antibodies. To further improve the circulating half-life of therapeutic IgG antibodies, a variety of biomolecular, cellular and evolutionary approaches have been employed and will be discussed. |
| 저자 |
정상택 |
| 소속 |
국민대 |
| 키워드 |
Antibody engineering; Therapeutic antibody; Antibody Fc; Serum half-lfie
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| E-Mail |
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