| 학회 |
한국공업화학회 |
| 학술대회 |
2019년 봄 (05/01 ~ 05/03, 부산 벡스코(BEXCO)) |
| 권호 |
23권 1호 |
| 발표분야 |
고분자_포스터 |
| 제목 |
Carbon Bonds Remaining in the microparticles synthesized by Stop Flow Lithography |
| 초록 |
Stop Flow Lithography (SFL) has been an effective technique to make anisotropic multifunctional hydrogel microparticles for various applications such as photonics, diagnostics, and drug delivery. However, when the particles are synthesized by crosslinking of oligomers in the precursor, the free-radical polymer network contains considerable carbon double bonds. Because they are chemically reactive and bio-toxic, these bond groups could result problems such as inhibiting the functionalities or bio-availability. We verified the existence of these double ends by thiol-ene click chemistry and also quantified the amount of them by changing conditions, such as UV intensity and exposure time. We present a simple method to eliminate them to solve the potential problems by linking PEG-SH to double ends via click reactions. The PEG-SH treated particles show much better biocompatibility, validated by the much higher cell viability compared with untreated ones. |
| 저자 |
문현준1, 이현지1, 구민희2, 이준호1, 양재문2, 봉기완1
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| 소속 |
1고려대, 2연세대 |
| 키워드 |
Flow lithography; Microparticles; Carbon double Bonds
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| E-Mail |
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