| 학회 |
한국고분자학회 |
| 학술대회 |
2009년 봄 (04/09 ~ 04/10, 대전컨벤션센터) |
| 권호 |
34권 1호 |
| 발표분야 |
기능성 고분자 |
| 제목 |
Optimization of the drug incorporation into PVA hydrogels |
| 초록 |
In this study, lidocaine loaded-poly(vinyl alcohol) (LL-PVA) hydrogels were designed and prepared by using γ-irradiation followed by freeze-thawing. A local anesthetic, lidocaine was incorporated into the PVA hydrogels with varying the drug loaded conditions to optimize the lidocaine release rate. When the PVA contents was 20 wt% and the irradiation dose at 25 kGy, the PVA based hydrogels can provide satisfactory physical properties such as a gel content and water absorptivity. The optimized LL-PVA hydrogel showed under in vitro conditions a rapid release the lidocaine over a couple of hours. It seems that the drug release rate is related to the state of the drug incorporated in the hydrogel matrix. |
| 저자 |
권희정, 임윤묵, 한설희, 안성준, 윤민호, 노영창
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| 소속 |
한국원자력(연) |
| 키워드 |
Gamma-irradiation; Lidocaine; PVA Hydrogel; Drug release
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| E-Mail |
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