| 학회 |
한국고분자학회 |
| 학술대회 |
2015년 가을 (10/06 ~ 10/08, 대구컨벤션센터(EXCO)) |
| 권호 |
40권 2호 |
| 발표분야 |
고분자합성 |
| 제목 |
Amphiphilic block copolymers as hydrophobic drug carrier |
| 초록 |
Formation of micelles, vesicles and emulsion with loading of hydrophobic probe (RS-2A) using amphiphilic block copolymers and the permeation studies will be discussed. In general, amphiphilic block copolymers are very attractive materials from both the scientific and the industrial point of view due to their hydrophobicity/hydrophilic behavior. In the present work styrene (St) is used as hydrophobic monomer/block and poly(ethylene glycol) (PEO) as hydrophilic block. PSt-b-PEO were prepared using RAFT polymerization. PSt were varied as 3k/4k whereas PEO was fixed as 8k. Micelles, vesicles and emulsion were prepared with loading of hydrophobic drug RS-2A by using prepared 3k/4kPSt-b-8kPEO block copolymers. The morphologies of micelles, vesicles and emulsion with dye were characterized using confocal laser scanning microscope. The diffusion of hydrophobic drug RS-2A through mimetic skin (hydrophobic and hydrophilic membranes) will be discussed in detail. |
| 저자 |
정인우1, Suguna Perumal2
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| 소속 |
1경북대, 2Kyungpook National Univ. |
| 키워드 |
Block copolymer; Amphiphilic; RS-2A
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| E-Mail |
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