| 학회 |
한국공업화학회 |
| 학술대회 |
2019년 봄 (05/01 ~ 05/03, 부산 벡스코(BEXCO)) |
| 권호 |
23권 1호 |
| 발표분야 |
생체재료_포스터 |
| 제목 |
Ion releasing bioreducible inorganic nanoparticles for enhancing angiogenic efficacy of hMSCs via cellular microenvironment control |
| 초록 |
Here, we report that Fe ion can be delivered into human mesenchymal stem cells (hMSCs) using bioreducible inorganic nanoparticle to enhance angiogenic paracrine factor secretion along with the improved cell migration capacity without causing cytotoxicity. Fe ion release from bioreducible inorganic nanoparticles was designed to be pH-sensitive manner so that low pH (pH 4.5-5.5) condition of the endosomes could start in situ Fe ion release from the nanoparticles. Treatment with AuFe NPs led mild level of reactive oxygen species increment in hMSCs through Fe ion released from our novel gold-iron nanoparticles (AuFe NPs). Fe ion delivered to hMSCs enhanced hypoxia-inducible factor-1 alpha expression which is a key factor of triggering angiogenic growth factor secretion from hMSCs. Compared to hMSCs without AuFe NPs treatment, hMSCs treated AuFe NPs resulted in significantly enhanced angiogenic growth factors. |
| 저자 |
김영환, 임광범, 방석호
|
| 소속 |
성균관대 |
| 키워드 |
Bioreducible; Nanoparticle; pH-sensitive; Stem cell; Therapeutic effect
|
| E-Mail |
|
