| 학회 |
한국공업화학회 |
| 학술대회 |
2004년 가을 (10/29 ~ 10/30, 호서대학교(아산캠퍼스)) |
| 권호 |
8권 2호 |
| 발표분야 |
고분자 |
| 제목 |
Core-shell type nanoparticles based on polyelectrolyte complexes of poly(ethylene glycol)-grafted low molecular water soluble chitosan |
| 초록 |
Core-shell type nanoparticles has advantages compared to plain nanoparticles, i.e. hydrophilic shell protect drug encapsulated core from attack of reticuloendothelial system (RES). In this study, we synthesized graft compolymers composed of Low molecular water soluble chitosan(LMWSC) and poly(ethylene gycol) (abbreviated as WSCP) to prepare core-shell type nanoparticles based on polyelectrolyte complexes between LMWSC backbone and anionic drug. Nanoparticulate polyelectrolyte complexes were formed through ultrasonication. WSCP were used to form core-shell type nanoparticles with WSCP and atRA and showed ability to form spherical nanoparticles. Particle sizes of WSCP-drug polyelectrolyte complexes was 50 - 800 nm according to the preparation condition. Loading efficiency of drug into chitosan polyelectrolyte complexes was over 60 % (w/w) at all of the formulation. This drug loading efficiency was higher than other types of drug carriers such as liposomes, conventional nanoparticles, and lipid nanoparticles. |
| 저자 |
김동곤1, 정영일1, 장미경1, 박준규1, 권중근2, 나재운1
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| 소속 |
1순천대, 2조선이공대 |
| 키워드 |
Core-shell type; low molecular water soluble chitosan
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| E-Mail |
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