| 초록 |
Solid-liquid extraction of paclitaxel from Taxus chinensis has been investigated to understand the effect of temperature, biomass/solvent ratio and solvent concentration on mechanism and kinetics of extraction. The paclitaxel concentration-time data were analyzed using a second-order kinetic model to determine extraction constant. Extraction temperature was observed to show a significant effect on paclitaxel yield, extraction rate and effective diffusion coefficient. The thermodynamic analysis showed that the enthalpy change (ΔH0) and entropy change (ΔS0) were both positive, while the Gibbs free energy change (∆G0) was negative and decreased when increasing the temperature. Thus, the extraction was more feasible when using a higher temperature. The results indicated that the extraction process for recovering paclitaxel from biomass was endothermic, irreversible, and spontaneous. |
