| 학회 |
한국화학공학회 |
| 학술대회 |
2015년 가을 (10/21 ~ 10/23, 일산 KINTEX) |
| 권호 |
21권 2호, p.1734 |
| 발표분야 |
생물화공 |
| 제목 |
Metabolic engineering of Escherichia coli for the production of poly (3-hydroxybutyrate-co-3-hydroxyvalerate) |
| 초록 |
Among PHA copolymers, [P(3HB-co-3HV)] is one of the important copolymer. So far, adding of second auxiliary carbon source was needed for the production of P(3HB-co-3HV). However, due to the toxicity of auxiliary carbon source, maintaining the balance between cell growth and polymer production was hard. Thus, we developed the E. coli can stably synthesize 3HB-CoA and 3HV-CoA in controlled ratio from glucose, and can efficiently synthesize P(3HB-co-3HV) without feeding auxiliary carbon source. [This work was supported by the Technology Development Program to Solve Climate Changes from National Research Foundation of Korea Development of systems metabolic engineering platform technologies for biorefineries; (NRF-2012-C1AAA001-2012M1A2A2026556).] |
| 저자 |
이상엽1, 박시재2, 송봉근3, 이승환4, 최용준5, 양정은6, 하지연7
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| 소속 |
1MBEL, 2Department of Chemical and Biomolecular Engineering, 3KAIST, 4Department of Environmental Engineering and Energy, 5Myongji Univ., 6Chemical Biotechnology Research Center, 7Department of Biotechnology and Bioengineering |
| 키워드 |
PHA; Metabolic engineering; Escherichia coli; Bio polymer
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| E-Mail |
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| 원문파일 |
초록 보기 |
