| 학회 |
한국고분자학회 |
| 학술대회 |
2014년 가을 (10/06 ~ 10/08, 제주 ICC) |
| 권호 |
39권 2호 |
| 발표분야 |
의료용 고분자 부문위원회 |
| 제목 |
Prediction of anti-arthritic drug efficacies by monitoring active matrix metalloproteinase-3 (MMP-3) levels in collagen-induced arthritic mice using the MMP-3 probe |
| 초록 |
The aim of this study was to investigate whether detection and monitoring of active MMP-3 could be useful to predict therapeutic drug responses in a collagen-induced arthritis(CIA) model. During the period of treatment with drugs such as methotrexate(MTX) or infliximab(IFX), MMP-3 mRNA and protein levels were correlated with fluorescence signals in arthritic joint tissues and in the serum of CIA mice. Also, bone density and erosion in the knee joints and the paws of CIA mice were measured with microCT, X-ray, and histology to confirm drug responses. In joint tissues and serum of CIA mice, strong fluorescence signals induced by action of active MMP-3 were significantly decreased when drugs were applied. The decrease in RA scores in drug-treated CIA mice led to fluorescence reductions, mainly due to down-regulation of MMP-3 RNA or protein. We hope that monitoring of active MMP-3 in patient using the MMP-3 diagnostic kit will be a promising tool for monitoring of RA therapy. |
| 저자 |
이애주1, 최성재2, 박경순3, 서동현4, 김한성4, 최귀원1, 권익찬1, 윤수영2, 윤인찬1, 김광명1
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| 소속 |
1한국과학기술(연), 2고려대, 3한국기초지원(연), 4연세대 |
| 키워드 |
rheumatoid arthritis; active MMP-3; therapeutic response monitoring; methotrexate; infliximab
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| E-Mail |
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